Recently Tim Ferriss got together with Dom D’Agostino to discuss cancer prevention. Dom is currently doing cutting edge research into the affect of things like fasting, ketosis and metformin on cancer cells.
During the interview, Tim poses a fascinating question…
“What if you found yourself with an aggressive form of cancer, what steps would you take?”
This hypothetical nature of this question is particularly interesting because it allows Dom to speculate on treatments that could take years to be verified. Scientific research can be frustrating, because often scientists “know” stuff 5 – 10 years ahead of the concepts gaining public consensus.
The first thing Dom says, is that if the doctor suggests you need something like chemotherapy… do it. Everything that follows would be supplemental, and not a replacement:
Dom’s 5 Step Protocol:
- Eat a ketogenic diet, and maintain high levels of ketones. The longer you stay in ketosis, the better tumour suppression you get. Additionally, ketosis has shown to both protect the body against the negative effects of chemotherapy, and also speed up recovery after sessions.
- Fast. Fasting is the quickest way to get into ketosis, and it promotes the bodies natural garbage clearing and healing mechanisms. He suggests ideally fasting during the day, and then eating a ketogenic diet in the evening.
- Supplement exogenous ketones, 2 – 4 times per day. That means products such as medium chain triglycerides (Dom likes Quest MCT Oil Powder) and coconut oil (make sure its cold pressed virgin oil). They can help with the on ramp to ketosis (helping avoid the initial stress on the body). Then once in ketosis, it can allow you to reach higher levels of ketone readings, which boost ones feeling of wellbeing, and improve the bodies tumour suppressing abilities.
- Take metformin to the point its causing side effects. He suggests titrating it, which means to start low (500mg)… and increase to the point you get some GI discomfort, back off slightly, and then stay there. Metformin works by suppressing glucose production in the liver. This lowers the bodies overall levels of glucose.
- Supplement Dichloroacetate – This activates a particular metabolic pathway called pyruvate dehydrogenise complex, and for reasons we don’t completely understand, it can cause cancer cells to die (apoptosis). Start at about 10mg per kg and don’t go above 50mg per kg. At 50mg per kg, or thereabouts, you start to damage the nerves (peripheral neuropathy).
Whilst the above is a quick summary, I’d highly recommend listening to the full podcast. Tim poses the above question at 1hr 46m 20s into the podcast, if you want to skip to that bit.
Additionally, there are lots of great takeaways from the discussion for those without cancer.
The core prevention techniques are fasting (intermittent and longer fasts) plus ketosis.
Ideally you would maintain a ketogenic diet, but Dom also posits research suggesting foods and supplements high in ketones can be beneficial, even on a non ketogenic diet.
“The FDA may see ketones as a drug. I see them as a fourth macronutrient. You have fats, proteins, and carbs. Ketones are an energy-containing molecule.”
– Dom D’Agostino
Since writing this, I emailed Dom a couple of questions I had stemming from the podcast. He was kind enough to write back, and the answers are below:
Question 1 – How best to use fasting to remove pre-cancerous cells?
Preamble: Dom suggested that its possible to use fasting to trigger our bodies’ natural garbage clearing mechanisms (autophagy) in order to clean up pre-cancerous cells. He suggested doing this at regular intervals.
Question: How long do the fasts need to be to achieve this affect, and how many times each year would be optimal?
Dom’s Answer: I would fast until you reach the metabolic zone (ketones up to level of glucose) and sustain that for at least 24-48 hours. This would put tremendous stress on existing or precancerous cells.
3 days minimum, and 3 times per year is a good starting point, but it may differ between people. What’s clear is that it gets easier with each attempt. I’m in touch with cancer patients doing this and they have stayed in remission and feel great.
-> If you’re interested in using fasting to remove pre-cancerous cells I’d suggest reading through Tim Ferriss’ protocol for a fast from Friday eve to Sunday eve. He has formulated a method to make it as painless + efficient as possible.
Question 2 – You mentioned dairy increasing your LDL count – which dairy products do you still consume?
Dom’s Answer: I have a mild allergy to dairy protein, so I minimize intake. In people that have no allergies I think small amounts of dairy are fine. Having a half pound of cheese/day is probably not ideal though, and there’s always people that go crazy with dairy on a ketogenic diet and complain they are not losing weight.
Heavy cream, sour cream and butter in large amount increased my LDL (and LDL-p). Simply replacing the heavy cream with coconut cream and cutting my sour cream consumption in half (to 2 servings/day) caused the LDL to go back down.
Question 3 – When it comes to artificial sweetener – are there any types that you suggest to avoid?
Question 4 – When it comes to ‘ketones on the go’ do you have any recommendations. Ideally things you can throw in a bag and they will survive warm temperature?
A key component for entering and maintaining ketosis is a ketone tester.The golden standard in these, as used by experts such as Tim Ferriss and Jimmy Moore is the Abott Precision Xtra. These are used to measure the level of ketones in your blood. The main use-cases are:
- For checking to see if you’ve entered ketosis. You might think “if I just stop eating carbs, eventually I will enter ketosis”. That’s true, but it misses one key point. Very often people start to feel bad after they drop carbs from their diet, and then they quit thinking it will be like this continuously. What has actually happened is that blood glucose level has decreased dramatically, but ketone levels haven’t risen high enough to take over and allow them to feel better. Using a ketone meter allows you to keep track, and ensure you reach adequate levels of ketosis before giving up.
- For checking how certain foods affect your bodies ketone levels (not everyone is the same). In particular which foods kick you straight out of ketosis, and which foods allow you to reach high ketone levels – the holy grail of ketosis.