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Dr. Rhonda Patrick’s Multivitamin Alternatives

Dr. Rhonda Patrick's Multivitamin Alternatives

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Dr. Rhonda Patrick’s multivitamin of choice is called Pure Encapsulations O.N.E. It’s a supplement that is easy to get hold of in the USA, and for some reason, quite difficult outside of the USA.

She has only publicly discussed using one other multivitamin; and that’s Thorne Prenatal, which she used during her pregnancy, and is designed for expecting mothers.

In this post I’d like to discuss a number of alternatives that contain very similar ingredients to Pure Encapsulations O.N.E.– such that hopefully you can find these in your home country. Whether its the UK, Canada, Australia or elsewhere.

In order to accurately compare supplements, I created a spreadsheet that lists all the ingredients of Pure Encapsulations O.N.E., then I compared the ingredients of others until I came up with a list of product that are very similar. You can view the spreadsheet here.

Warnings (don’t make the mistakes I did!)

  • I tried buying supplements from iHerb, and whilst they had a good selection, the import fees to the UK were super expensive! Unless you’re 100% confident the import fees in your country are low, avoid at all costs buying from foreign stores. Unfortunately, a lot of foreign stores hide / make difficult to ascertain the fact that they’re shipping from outside your country, so be alert.
  • In particular have noticed a lot of Canadian Amazon sellers ship from USA. That could be easily overlooked! When buying on Amazon, click the link that says 1 new from (it may say a number other than 1, but that was just an example) – and check the table which shows who the sellers are and which geographical locations they are shipping from.
  • As part of my research I came across another supplement by Pure Encapsulations called All-In-One. However, sadly, this multivitamin was not cut from the same cloth as O.N.E, and misses off a lot of the essential micronutrients that O.N.E has. Despite it having the same manufacturer.

Thorne Research – Basic Nutrients 2 / Day

Dr. Rhonda Patrick's Multivitamin Alternatives Dr. Rhonda Patrick's Multivitamin Alternatives


Availability: Thorne

Thorne Research brand is Dr. Rhonda Patrick’s favorite choice of supplements. She currently uses it for her magnesium citramate, vitamin D3, Meriva and more.

This particular supplement is very nutritionally diverse, and provides a good alternative to O.N.E. It contains folate as opposed to folic acid, which is great for those with the MTHFR im.


  • Noticeably it doesn’t contain Iron or Potassium. However, for red meat eaters the former may be acceptable.
  • Its not cheap, its around $30 for a 1 month supply (each pack contains 60 capsules, and a daily serving is 2)

Now Foods Special Two

Dr. Rhonda Patrick's Multivitamin AlternativesDr. Rhonda Patrick's Multivitamin Alternatives


Availability: Amazon USA

Now is a reputable brand that Rhonda has discussed using (for other products) in the past.  This particular multivitamin by now covers a very broad spectrum of the essential micronutrients our body needs. Each serving is 4 pills, and a 120 capsule tub contains 30 days of servings.

It actually has the broadest coverage of any of the multivitamins I looked compared. It even has copper, which O.N.E misses off (not sure why!)

In addition to the essential micronutrients, they have also included some popular plant and herb extracts, such as spirulina, chlorella, green tea extract etc.


  • Contains Folic acid rather than folate. A negative for those with the MTHFR polymorphism that leads to poor processing of folic acid (~60% of population).
  • Potential negative is that it contains so many “extra” things on top of the micronutrients, purists (like myself) may prefer it just sticks to vitamins & minerals.
  • Reasonably high monthly cost – each tub is about $30 and lasts a month (although that is $1 a day, so not crazy!)

Product Comparison Table (Vitamin & Mineral Content)

The below table aims to list out all of the essential micronutrients, then compares Rhonda’s supplement with the two mentioned above. This should give a comprehensive picture of their strengths and weaknesses.

 MicronutrientRecommended Daily Allowance (RDA*), or where not available, Adequate Intake figures (AI†)Pure Encapsulations O.N.EThorne Research – Basic Nutrients 2 / DayNow Foods, Special Two, Multi Vitamin
1Thiamin (vitamin B1)1.1mg*3mg50mg50mg
2Riboflavin (vitamin B2)1.1mg*3mg12mg50mg
3Niacin (vitamin B3) (nicotinic acid, nicotinamide)14mg*20mg80mg50mg
4Pantothenic Acid5mg†10mg45mg50mg
6Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine)1.3mg*4mg20mg50mg
7Folate or Folic Acid400mcg*400mcg (folate)400mcg (folate)400mcg (folic acid)
8Vitamin B12 (cobalamin)2.4mcg*500mcg600mcg100mcg
9Ascorbic acid (vitamin C)2.4 μg*180mg250mg500mg
10Vitamin A (retinol, retinal, retinoic acid)900mcg RAE / 700mcg RAE3,750iu5,000iu10,000iu
11Vitamin D15-20mcg2,000iu2,000iu400iu
12Vitamin E12mg30iu20iu200iu
13Vitamin K120mcg X400mcgX
14Calcium1,000mg X30mg100mg
15Magnesium400mg males/310mg females X20mg50mg
16Chromium35mcg males/25mcg females200mcg400mcg100mcg
17Copper900mcg 750mcg1mg
19Iron8mg male/18mg female  10mg
20Manganese2.3 mg* male;/1.8 mg* female2mg3mg5mg
23Zinc11mg male / 8mg female25mg15mg15mg
I’ve included Omega 3 & 6 in this list, so that its a complete list of essential micronutrients (well, minus the essential amino acids) – but of course, multivitamin products generally don’t include omega 3+6, you’re expected to buy separately.
24Omega 3 – EPA / DHA
500mg is minimum – no strict guidelines on intake though currently
25Omega 6
Ideally daily intake wants to be 1:1 ratio with Omega-3.
The below 5 are rarely found in multivitamins, apart from Potassium. Perhaps because they’re relatively abundant in foods.
26Phosphorus  X XX
27Sulfur  XXX
28Sodium  X X X
29Potassium4700mg X X50mg
30Chloride  X X X
The below is not a problem for most people, if they consume meat & eggs, more an issue for vegetarians
31CholineFrom 500mg/day X X50mg
Essential micronutrients #32-#40 should cover the 9 essential amino acids. However, these only become an issue for vegetarians and vegans. For most people eating meat, dairy, fish, and eggs, they’re getting plenty.

Honorable Mention

Optimum Nutrition – Opti-Men

Availability: Amazon USA 

Dr. Rhonda Patrick's Multivitamin Alternatives Dr. Rhonda Patrick's Multivitamin Alternatives

  • Comprehensive micronutrient coverage
  • Generally a well known brand, so should be available in many locations
  • Contains folic acid instead of folate
  • Includes a lot of additional herbs & plants, that may or may not be desirable

If you liked this article please visit this other article about other Dr. Rhonda Patrick’s recommendations on supplements:

Dr. Rhonda Patrick’s Supplements

If you want to learn about supplements other than those on Dr. Rhonda Patrick’s recommended list, then visit this article as well:

Tim Ferris Supplements

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