Diet General Supplements

Dr. Rhonda Patrick Probiotic Supplement Choice

Dr. Rhonda Patrick Probiotic Supplement Choice

Dr. Rhonda Patrick is a big advocate of a healthy gut biome. She aims to achieve this primarily through a nutritionally diverse diet that’s rich in fiber. On top of this, she tops up her gut bacteria with supplemental probiotics.

Until recently she was using the probiotic VSL #3. To quote her:

I’ve changed my probiotic to VSL#3. It has 10X the bugs than any other brand and 25 published studies showing efficacy in IBS, IBD, colitis, and c.diff.


She has also talked about VSL #3 on Twitter:

Tweet between Kieran Wild and Dr. Rhonda Patrick about VSL #3.

And its not just Rhonda taking it; Tim Ferriss is also a fan:

Tweet between Josh Highland and Tim Ferriss about VSL #3

However, recently Dr. Rhonda Patrick changed her probiotic choice to Visbiome.

Dr. Rhonda Patrick holding a box of Visbiome. Image of a box of Visbiome.

Rhonda states that Visbiome offers almost the exact same formulation as VSL#3, at about $16 less per box of 30 packets.

See this Visbiome vs VSL#3 comparison table to understand the minor differences.

VSL#3 vs Visbiome – The History
VSL#3 was originally created by Professor De Simone in Italy. The De Simone probiotic formulation was licensed to VSL Pharmaceuticals, be marketed under the trademarked term VSL#3. This agreement went on for many years, in which time they published 25 different studies on its effectiveness. When this agreement expired in January 2016, De Simone opted to partner with ExeGi Pharma, and created Visbiome. It uses the same formulation VSL#3 were using prior to Jan 2016. This now means there are two companies offering almost the exact same formulations (again, see the comparison table to understand their minor differences).

Pricing – Pills vs Sachets

Visbiome is the Rolls Royce of probiotics, and it doesn’t come cheap.

 Visbiome PillsVisbiome Sachets
Live Bacteria Count112.5billion450 billion
Price per serving$1.7 per serving
– Each $51 tub contains 60 pills, with 2 pills per serving
$3 per serving
– $90 for 30 sachets, 1 sachet per serving

Typically Dr. Rhonda Patrick takes a maintenance dose of probiotics between once per week and once every 2 weeks. Specifically she takes the sachets containing 450 billion live bacteria:

Image of tweet between Adam Chudy and Dr. Rhonda Patrick

What Dr. Rhonda Patrick leaves out in the tweet, is that the packet (sachet) form contains 4x as many live bacteria as a serving via the pills.

Recently, while she has been breastfeeding, she has been taking 1 sachet per day.


Rhonda knows so much about this subject, compared to the layman, that I tend to take her advice. She talks about two main problems with other probiotics:

  • They often die when left unrefrigerated
  • They don’t contain a meaningful amount of live bacteria

If you’re set on taking a probiotic other than Visbiome or VSL #3, it would be worth checking if there are any peer reviewed studies backing up the products efficacy. For studies on VSL #3, search it on Google Scholar.

Further Research by Dr. Rhonda Patrick

While supplementing probiotics like Visbiome or VSL #3 is useful, it shouldn’t replace a nutritionally diverse diet, rich in plant fiber. To learn more about this subject, take a look at the following Dr. Rhonda Patrick’s interview with Dr. Erica & Dr. Justin Sonnenburg

If you like this article and want to learn more about Dr. Rhonda Patrick please visit these other articles:

Dr. Rhonda Patrick’s Smoothie Recipe 

Dr. Rhonda Patrick’s Diet Ideas

Dr. Rhonda Patrick’s Supplements of Choice



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  • Hi, I recently had a baby and my natural water big didn’t work out. After 72 hours, I had to have a emergency cs. I was wondering if I can take this while breast feeding? Thank you so much.

  • wow, that’s an expensive one and virtually no reviews, i’m seeing a pattern with all these people; joe, tim, rhonda, dom, etc. they keep advertising products that seem suboptimal, i get that they too need to make money, but i’m kind of losing faith here.